Journal article
Muscle grip strength predicts incident type 2 diabetes: Population-based cohort study
JJ Li, GA Wittert, A Vincent, E Atlantis, Z Shi, SL Appleton, CL Hill, AJ Jenkins, AS Januszewski, RJ Adams
Metabolism Clinical and Experimental | W B SAUNDERS CO-ELSEVIER INC | Published : 2016
Abstract
Objectives To determine the longitudinal relationship of muscle mass and strength with incident type 2 diabetes, and previously unstudied mediating effects of testosterone and inflammation. Methods Community-dwelling male participants (aged ≥ 35 years) of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study underwent biomedical assessment in 2002-2006 and 2007-2010, including hand grip strength (dynamometer), testosterone and inflammatory markers. Body composition (dual-energy X-ray absorptiometry) was assessed at baseline only. Incident type 2 diabetes was defined as a self-reported doctor diagnosis, diabetes medication use, fasting plasma glucose ≥ 7.0 mmol/L, or g..
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Awarded by ResMed Foundation
Funding Acknowledgements
The MAILES cohort study has been supported by the National Health and Medical Research Council of Australia (grant number 627227), the University of Adelaide, the South Australian Department of Health, the Florey Foundation, and the South Australian Premier's Science and Research Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.